Spike is used operationally by more observatories than any other planning and scheduling system. Operational sites include:
- Hubble Space Telescope (HST)
- Far Ultraviolet Spectroscopic Explorer (FUSE)
- ESO's Very Large Telescope (VLT)
- Subaru (Japanese National 8m telescope)
- Space Infrared Telescope Facility (SIRTF)
- Advanced X-ray Astrophysics Facility (AXAF)
- German Space Operations Center (GSOC/DLR)
- Extreme Ultraviolet Explorer (EUVE)
- Advanced Satellite for Cosmology and Astrophysics (ASCA)
- X-ray Timing Explorer (XTE)
Interval Logic Corporation has applied Spike scheduling techniques to semiconductor manufacturing.