New Spitzer images of M101 from 3.5 to 160~\micron\ are presented. Preliminary analysis focusing on the dependence of the infrared spectral energy distribution of HII regions as a function of metallicity finds that the mid-infrared PAH features become weak or absent between metallicities of 8.5 and 8.1. There is also a trend towards hotter dust temperature as metallicity decreases.
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Karl D. Gordon
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